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Among the synaptic proteins, cell adhesion molecules (neuroligins (NLGNs) 176 and neurexins (NRXNs) 61 ), postsynaptic scaffolding proteins (SH3 and multiple ankyrin repeat domains protein (SHANK), 177 glutamate receptors (NMDAR subunit, GluN2B), 178 inhibitory GABA A receptor subunits 3 and 3 (GABRA3 and GABRB3, respectively) 179 and permeable ion channels (voltage-dependent calcium channel subunit 1C (CACNA1C) 180 and sodium channel protein type 1 subunit- (SCN1A) 181 ) are reported to be important signal transduction molecules associated with ASD
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Data from in vivo study also revealed that a high-fat diet accelerates the proliferation of prostate tumors and increased M2/M1 macrophage ratio and myeloid-derived suppressor cells fraction via interleukin (IL)-6/phospho-signal transducer and activator of transcription 3 (pSTAT3) signaling [43]
10.1183/13993003.02022-2022 3 AdlerK
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